Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8084927 | 0.89 | ALOX5 (0.56) | ALOX5CDK2PTGS2PIK3CDPIK3CA | |
| SCHEMBL8072504 | 0.89 | ALOX5 (0.56) | ALOX5CDK2KDM4EALDH1A1MAPT | |
| SCHEMBL8080562 | 0.89 | ALOX5 (0.56) | ALOX5NQO2CDK2KDM4EMAPT | |
| SCHEMBL8081502 | 0.89 | ALOX5 (0.55) | ALOX5CDK2KDM4ERAB9ANPC1 | |
| SCHEMBL2952410 | 0.89 | ALOX5 (0.71) | ALOX5KDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL8080585 | 0.88 | ALOX5 (0.53) | ALOX5KDRCDK2ALDH1A1HSP90AA1 | |
| SCHEMBL8085115 | 0.88 | ALOX5 (0.53) | ALOX5KDRKDM4EALDH1A1RAB9A | |
| SCHEMBL8072655 | 0.88 | ALOX5 (0.54) | ALOX5CDK2KDM4EMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8072479 | 0.87 | ALOX5 (0.53) | ALOX5CDK2KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL8080428 | 0.86 | ALOX5 (0.53) | ALOX5KDRCDK2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |