Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.53 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8072770 | 0.90 | PARP1 (0.48) | ALOX5APPACHEALDH1A1SMN1; SMN2 | |
| SCHEMBL8084967 | 0.88 | ALOX5 (0.56) | ALOX5ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2951387 | 0.88 | ALOX5 (0.53) | ALOX5APPACHEALDH1A1SMN1; SMN2 | |
| SCHEMBL8080562 | 0.86 | ALOX5 (0.56) | ALOX5NPSR1MAPTKDM4E | |
| SCHEMBL8084927 | 0.86 | ALOX5 (0.56) | ALOX5MEN1KMT2A | |
| SCHEMBL8072504 | 0.86 | ALOX5 (0.56) | ALOX5ALDH1A1SMN1; SMN2HPGDMEN1 | |
| SCHEMBL8081502 | 0.86 | ALOX5 (0.55) | ALOX5SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL2952410 | 0.86 | ALOX5 (0.71) | ALOX5ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8081527 | 0.86 | ALOX5 (0.48) | ALOX5APPACHEALDH1A1SMN1; SMN2 | |
| SCHEMBL8086646 | 0.85 | ALOX5 (0.51) | ALOX5APPACHEALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |