Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 4/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.33 |
| ▸ | PRCP | P42785 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8084132 | 0.78 | SIGMAR1 (0.38) | SIGMAR1OPRM1OPRL1 | |
| SCHEMBL8087174 | 0.78 | SIGMAR1 (0.38) | SIGMAR1OPRM1OPRL1 | |
| SCHEMBL8085478 | 0.78 | SIGMAR1 (0.38) | SIGMAR1OPRM1OPRL1 | |
| SCHEMBL8091606 | 0.77 | OPRD1 (0.34) | OPRD1CYP3A4 | |
| SCHEMBL8098119 | 0.77 | OPRD1 (0.34) | OPRD1CYP3A4 | |
| SCHEMBL8080724 | 0.74 | MAPT (0.42) | CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3706694 | 0.73 | OPRD1 (0.38) | OPRD1OPRM1OPRK1OPRL1 | |
| SCHEMBL4184268 | 0.73 | OPRD1 (0.38) | OPRD1OPRM1OPRK1OPRL1 | |
| Hydrochloric Acid SCHEMBL4184756 | 0.72 | OPRD1 (0.37) | OPRD1SIGMAR1OPRM1OPRK1OPRL1 | |
| SCHEMBL380306 | 0.70 | OPRD1 (0.39) | OPRD1HPGDOPRM1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009013535-A1 | 2-AZABICYCLO(2.2.2)OCTANE DERIVATIVES AS MODULATORS OF THE GLYCINE TRANSPORTER I RECEPTOR | ASTRAZENECA AB (SE) | 2009-01-29 | — | — | WO | disclosed |