Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | IDH2 | P48735 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.32 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8078886 | 1.00 | MEN1 (0.38) | MEN1KMT2AHSD11B1DHFRHTT | |
| SCHEMBL8081813 | 0.97 | MEN1 (0.40) | MEN1KMT2AHSD11B1DHFRHTT | |
| SCHEMBL8069549 | 0.91 | HTT (0.36) | MEN1KMT2AHSD11B1HTTSMN1; SMN2 | |
| SCHEMBL8078914 | 0.91 | HTT (0.36) | MEN1KMT2AHSD11B1HTTSMN1; SMN2 | |
| SCHEMBL8319157 | 0.91 | DHFR (0.39) | MEN1KMT2AHSD11B1DHFRHTT | |
| SCHEMBL8069546 | 0.87 | LMNA (0.37) | MEN1KMT2AHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8077242 | 0.87 | LMNA (0.37) | MEN1KMT2AHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8319788 | 0.87 | LMNA (0.36) | MEN1KMT2AHSD11B1DHFRHTT | |
| SCHEMBL8078953 | 0.86 | HSD11B1 (0.36) | MEN1KMT2AHSD11B1HTTALDH1A1 | |
| SCHEMBL8645082 | 0.85 | DHFR (0.36) | MEN1KMT2AHSD11B1DHFRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6106993-A | HIGHLY SENSITIVE TO ACTINIC RADIATION SUCH AS DEEP-UV, ELECTRON BEAM AND X-RAY, CAN BE DEVELOPED WITH ALKALINE AQUEOUS SOLUTION TO FORM A PATTERN, AND IS THUS SUITABLE FOR USE IN A FINE PATTERNING TECHNIQUE | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2000-08-22 | — | — | US | disclosed |