Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | SMAD3 | P84022 | 3/20 | 0.44 |
| ▸ | P4HB | P07237 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8327107 | 0.88 | MAPT (0.46) | KMT2AMEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4816680 | 0.82 | KMT2A (0.63) | KMT2AMEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4824905 | 0.79 | KMT2A (0.52) | KMT2AMEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4817176 | 0.78 | KMT2A (0.54) | KMT2AMEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL23457049 | 0.77 | ADRA2A (0.47) | KMT2AMEN1CYP2D6LMNABLM | |
| SCHEMBL31682604 | 0.77 | ADRA2A (0.47) | KMT2AMEN1CYP2D6LMNABLM | |
| SCHEMBL20157583 | 0.76 | LMNA (0.46) | KMT2AMEN1CYP1A2CYP2D6PTGS2 | |
| SCHEMBL30057731 | 0.76 | AOC3 (0.47) | CYP2D6LMNANPC1RAB9A | |
| SCHEMBL20157585 | 0.75 | LMNA (0.45) | KMT2AMEN1CYP2D6ALDH1A1LMNA | |
| SCHEMBL18113374 | 0.75 | LMNA (0.45) | KMT2AMEN1CYP2D6HTR1APTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |