Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 1.00 |
| ▸ | RET | P07949 | 1/20 | 0.66 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.55 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8093519 | 0.90 | EGFR (1.00) | EGFRERBB2 | |
| SCHEMBL7966781 | 0.86 | EGFR (0.76) | EGFRRETRIPK2 | |
| SCHEMBL8524535 | 0.81 | EGFR (0.82) | EGFRRETERBB2 | |
| SCHEMBL8976728 | 0.80 | RET (1.00) | EGFRRETRIPK2 | |
| SCHEMBL2103341 | 0.79 | EGFR (0.82) | EGFRERBB2 | |
| SCHEMBL15052504 | 0.79 | BRAF (0.76) | EGFRRET | |
| SCHEMBL11953092 | 0.79 | RET (0.67) | EGFRRETERBB2RIPK2 | |
| SCHEMBL7978781 | 0.78 | EGFR (0.78) | EGFRRETERBB2 | |
| SCHEMBL7978783 | 0.78 | EGFR (0.78) | EGFRRETERBB2 | |
| SCHEMBL1733829 | 0.77 | EGFR (0.76) | EGFRRETERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153617-A | Irreversible bicyclic inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY (US) | 2000-11-28 | — | — | US | claimed |
| WO-1999006396-A1 | IRREVERSIBLE BICYCLIC INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | claimed |
| US-6153617-A | Irreversible bicyclic inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY (US) | 2000-11-28 | — | — | US | disclosed |
| WO-1999006396-A1 | IRREVERSIBLE BICYCLIC INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |