Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 7/20 | 0.41 |
| ▸ | MTOR | P42345 | 5/20 | 0.41 |
| ▸ | NAMPT | P43490 | 8/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8091160 | 0.95 | NAMPT (0.38) | PIK3CAMTORNAMPTPIK3CDPIK3CB | |
| SCHEMBL8089000 | 0.92 | PIK3CD (0.40) | PIK3CAMTORNAMPTPIK3CDCA12 | |
| SCHEMBL8100146 | 0.90 | CA1 (0.41) | PIK3CAMTORNAMPTPIK3CDPIK3CB | |
| SCHEMBL8093138 | 0.90 | NAMPT (0.40) | PIK3CAMTORNAMPTPIK3CDPIK3CB | |
| SCHEMBL8090241 | 0.89 | NAMPT (0.43) | PIK3CAMTORNAMPTPIK3CDPIK3CB | |
| SCHEMBL8090391 | 0.88 | CA1 (0.41) | PIK3CAMTORNAMPTPIK3CDCA12 | |
| SCHEMBL8104051 | 0.88 | NAMPT (0.38) | PIK3CAMTORNAMPTPIK3CD | |
| SCHEMBL8098775 | 0.88 | CA1 (0.43) | PIK3CAMTORNAMPTPIK3CDPIK3CB | |
| SCHEMBL8089917 | 0.87 | PIK3CA (0.39) | PIK3CAMTORNAMPTPIK3CDPIK3CG | |
| SCHEMBL8093959 | 0.87 | PIK3CA (0.38) | PIK3CAMTORNAMPTPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |