Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 6/20 | 0.39 |
| ▸ | MTOR | P42345 | 5/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.36 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.36 |
| ▸ | NAMPT | P43490 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8083973 | 0.93 | ALDH1A1 (0.43) | PIK3CAMTORPIK3CGKMT2APIP4K2A | |
| SCHEMBL8094619 | 0.91 | PIP4K2A (0.40) | PIK3CAMTORPIK3CGKMT2APIP4K2A | |
| SCHEMBL8104053 | 0.90 | CA2 (0.41) | PIK3CAMTORPIK3CGPIK3CDNAMPT | |
| SCHEMBL8097966 | 0.89 | KIF11 (0.37) | PIK3CAMTORPIK3CGKMT2APIK3CD | |
| SCHEMBL8097712 | 0.89 | KMT2A (0.39) | PIK3CAMTORPIK3CGKMT2APIP4K2A | |
| SCHEMBL8092637 | 0.89 | KMT2A (0.42) | PIK3CAMTORPIK3CGKMT2APIP4K2A | |
| SCHEMBL8090246 | 0.89 | PIK3CA (0.42) | PIK3CAMTORPIK3CGKMT2APIP4K2A | |
| SCHEMBL8089000 | 0.88 | PIK3CD (0.40) | PIK3CAMTORKMT2APIK3CDNAMPT | |
| SCHEMBL8104051 | 0.88 | NAMPT (0.38) | PIK3CAMTORPIK3CDNAMPT | |
| SCHEMBL8097257 | 0.88 | ALDH1A1 (0.41) | PIK3CAMTORPIK3CGKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |