Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 5/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 5/20 | 0.40 |
| ▸ | GRIA3 | P42263 | 5/20 | 0.40 |
| ▸ | GRIA4 | P48058 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8081073 | 0.79 | TSHR (0.43) | MAPTALDH1A1HTTMEN1USP2 | |
| SCHEMBL8083071 | 0.77 | MAPT (0.40) | MAPTMITFALDH1A1HTTGRIA1 | |
| SCHEMBL1693744 | 0.70 | MAPT (0.38) | MAPTMITFALDH1A1HTTGRIA1 | |
| SCHEMBL20564985 | 0.68 | NPSR1 (0.40) | MAPTALDH1A1HTTMEN1USP2 | |
| SCHEMBL9025866 | 0.65 | LMNA (0.67) | MAPTHTTMEN1USP2LMNA | |
| SCHEMBL1840378 | 0.65 | ALDH1A1 (0.51) | MAPTMITFALDH1A1HTTGRIA1 | |
| SCHEMBL3998281 | 0.63 | CYP1A2 (0.55) | MAPTALDH1A1GRIA1GRIA2GRIA3 | |
| SCHEMBL16057276 | 0.62 | CYP3A4 (0.46) | MAPTMITFALDH1A1HTTGRIA1 | |
| SCHEMBL9555764 | 0.62 | GRIA1 (0.50) | MAPTMITFALDH1A1HTTGRIA1 | |
| SCHEMBL12878893 | 0.62 | GRIA1 (0.46) | MAPTALDH1A1HTTGRIA1GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6025489-A | Tricyclic pteridinones and a process for their preparation | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-02-15 | — | — | US | disclosed |
| EP-0429149-B1 | Tricyclic pteridinones and a process for their preparation | BERLEX LAB (US) | 2000-01-05 | — | — | EP | disclosed |
| US-5854419-A | Tricyclic pteridinones and a process for their preparation | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-12-29 | — | — | US | disclosed |
| US-5602252-A | Tricyclic pteridinones and a process for their preparation | BERLEX LABORATORIES, INC. | 1997-02-11 | — | — | US | disclosed |