Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7923982 | 0.80 | KCNN4 (0.41) | KCNN4CYP1A2CYP3A4RECQLKIF11 | |
| SCHEMBL27548806 | 0.80 | KCNN4 (0.41) | PTPN1KCNN4CYP1A2CYP3A4RECQL | |
| SCHEMBL28777735 | 0.80 | KCNN4 (0.41) | KCNN4CYP1A2CYP3A4RECQLKIF11 | |
| SCHEMBL12914773 | 0.80 | KCNN4 (0.50) | KCNN4CYP1A2CYP3A4RECQLCYP2C19 | |
| SCHEMBL31370489 | 0.80 | CYP1A2 (0.58) | KCNN4CYP1A2CYP3A4RECQLKIF11 | |
| SCHEMBL28769203 | 0.78 | CYP1A2 (0.41) | PTPN1KCNN4CYP1A2CYP3A4RECQL | |
| SCHEMBL27538108 | 0.78 | KCNN4 (0.39) | PTPN1KCNN4CYP1A2CYP3A4RECQL | |
| SCHEMBL30564476 | 0.78 | KIF11 (0.50) | KCNN4CYP1A2CYP3A4RECQLKIF11 | |
| SCHEMBL29872151 | 0.78 | L3MBTL1 (0.49) | CYP1A2CYP2C19HIF1AKDM4EMEN1 | |
| SCHEMBL12286073 | 0.77 | ALOX5 (0.51) | KCNN4CYP3A4RECQLCYP2C19MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757982-B1 | Biphenylic compounds, process for their preparations and intermediates for this process, their use as 5-alpha-reductase inhibitors and pharmaceutical compositions containing them | HOECHST MARION ROUSSEL INC (FR) | 2000-09-20 | — | — | EP | disclosed |
| US-5965763-A | Biphenyl compounds | HOECHST MARION ROUSSEL (FR) | 1999-10-12 | — | — | US | disclosed |
| US-5827887-A | 5-ALPHA REDUCTASE INHIBITORS | ROUSSEL UCLAF (FR) | 1998-10-27 | — | — | US | disclosed |
| EP-0757982-A1 | Biphenylic compounds, process for their preparations and intermediates for this process, their use as 5-alpha-reductase inhibitors and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1997-02-12 | — | — | EP | disclosed |