Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.55 |
| ▸ | DRD1 | P21728 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6056146 | 0.98 | KCNH2 (0.59) | KCNH2SIGMAR1CHRM2HTR1AADRA2A | |
| SCHEMBL8086575 | 0.98 | KCNH2 (0.59) | KCNH2SIGMAR1CHRM2HTR1AADRA2A | |
| Hydrochloric Acid SCHEMBL3028479 | 0.96 | KCNH2 (0.57) | KCNH2SIGMAR1CHRM2HTR1AADRA2A | |
| SCHEMBL1299303 | 0.94 | CHRM2 (0.62) | KCNH2SIGMAR1CHRM2HTR1AADRA2A | |
| SCHEMBL6706300 | 0.89 | KCNH2 (0.66) | KCNH2SIGMAR1CHRM2HTR1AADRA2A | |
| SCHEMBL11699577 | 0.87 | SIGMAR1 (0.69) | KCNH2SIGMAR1CHRM2HTR1AADRA2A | |
| SCHEMBL10662405 | 0.87 | SIGMAR1 (0.69) | KCNH2SIGMAR1CHRM2HTR1AADRA2A | |
| Trolamine SCHEMBL671041 | 0.85 | KCNH2 (0.68) | KCNH2SIGMAR1CHRM2HTR1AADRA2A | |
| Trolamine SCHEMBL11590482 | 0.85 | KCNH2 (0.68) | KCNH2SIGMAR1CHRM2HTR1AADRA2A | |
| SCHEMBL6567560 | 0.85 | OPRK1 (0.60) | OPRM1DRD3TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711763-B1 | 1,4-DI(PHENYLALKYL)PIPERAZINE DERIVATIVES | SANTEN PHARMACEUTICAL CO LTD (JP) | 2000-10-18 | — | — | EP | disclosed |
| US-5736546-A | BRAIN DISORDERS; PSYCHOLOGICAL DISORDERS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1998-04-07 | — | — | US | disclosed |
| EP-0711763-A1 | NOVEL 1,4-DI(PHENYLALKYL)PIPERAZINE DERIVATIVE | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1996-05-15 | — | — | EP | disclosed |