Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.37 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.37 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.37 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.37 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.37 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.37 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.37 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.37 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.37 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.37 |
| ▸ | CACNG1 | Q06432 | 1/20 | 0.37 |
| ▸ | CACNB2 | Q08289 | 1/20 | 0.37 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8765779 | 0.75 | MC4R (0.37) | MAPTALDH1A1MAOBKDM4EHTT | |
| SCHEMBL9407223 | 0.67 | CACNB4 (0.37) | ALDH1A1MEN1KMT2ACACNA1BCACNB4 | |
| SCHEMBL5273291 | 0.63 | ALDH1A1 (0.36) | MAPTALDH1A1MEN1KMT2AELANE | |
| SCHEMBL7502415 | 0.62 | ALDH1A1 (0.41) | MAPTALDH1A1KMT2AMAOBKDM4E | |
| SCHEMBL7114933 | 0.60 | KMT2A (0.37) | MAPTALDH1A1MEN1KMT2AELANE | |
| SCHEMBL27673225 | 0.59 | CPA1 (0.47) | ALDH1A1HTTCYP1A2CYP2C19 | |
| SCHEMBL73253 | 0.59 | CPA1 (0.47) | ALDH1A1HTTCYP1A2CYP2C19 | |
| SCHEMBL5448618 | 0.58 | MMP9 (0.64) | MAPTALDH1A1KMT2ACACNA1BELANE | |
| SCHEMBL11192725 | 0.58 | HTT (0.47) | MAPTALDH1A1KMT2AELANECA2 | |
| SCHEMBL460010 | 0.58 | PTPRF (0.47) | MAPTMEN1KMT2ACA2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863874-B1 | PROCESS FOR PREPARING DIOXOAZABICYCLOHEXANES | PFIZER LTD (GB) | 2000-12-27 | — | — | EP | disclosed |
| EP-0818446-B1 | Process for preparing 2,4-dioxo-3-azabicyclo(3.1.0)hexanes | PFIZER LTD (GB) | 2000-11-02 | — | — | EP | disclosed |
| EP-0863874-A1 | PROCESS FOR PREPARING DIOXOAZABICYCLOHEXANES | Pfizer Limited (GB) | 1998-09-16 | — | — | EP | disclosed |
| EP-0818446-A1 | Process for preparing 2,4-dioxo-3-azabicyclo(3.1.0)hexanes | Pfizer Limited (GB) | 1998-01-14 | — | — | EP | disclosed |
| EP-0629189-B1 | PREPARATION OF INTERMEDIATES IN THE SYNTHESIS OF QUINOLINE ANTIBIOTICS | PFIZER (US) | 1997-08-06 | — | — | EP | disclosed |
| WO-1997019921-A1 | PROCESS FOR PREPARING DIOXOAZABICYCLOHEXANES | PFIZER LIMITED (GB) | 1997-06-05 | — | — | WO | disclosed |
| US-5298629-A | Intermediates in the synthesis of quinoline antibiotics | PFIZER INC. (US) | 1994-03-29 | — | — | US | disclosed |
| US-5256791-A | Preparation of intermediates in the synthesis of quinoline antibiotics | PFIZER INC. (US) | 1993-10-26 | — | — | US | disclosed |