Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 4/20 | 0.34 |
| ▸ | MAOB | P27338 | 4/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | KCNA4 | P22459 | 1/20 | 0.33 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.33 |
| ▸ | KCNAB1 | Q14722 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8083733 | 0.75 | MAPT (0.37) | KDM4EMAPTHTTALDH1A1HSD11B1 | |
| SCHEMBL8766756 | 0.70 | MAOA (0.48) | MC4RMAOAMAOBGBA1KDM1A | |
| SCHEMBL9407228 | 0.68 | KCNA4 (0.36) | ALDH1A1KCNA4KCNA1KCNAB1 | |
| SCHEMBL16608271 | 0.65 | MAOA (0.36) | MC4RMAOAMAOBGBA1KDM1A | |
| SCHEMBL16608218 | 0.65 | LMNA (0.42) | MC4RALDH1A1MAOAMAOBGBA1 | |
| SCHEMBL18373227 | 0.65 | MAOA (0.36) | MC4RMAOAMAOBGBA1KDM1A | |
| SCHEMBL7502415 | 0.65 | ALDH1A1 (0.41) | KDM4EMAPTHTTALDH1A1HSD11B1 | |
| SCHEMBL9129297 | 0.62 | MC4R (0.39) | MC4RMAPTALDH1A1HSD11B1CTSD | |
| SCHEMBL7867641 | 0.62 | MC4R (0.49) | MC4RMAPTALDH1A1GBA1 | |
| SCHEMBL5273291 | 0.62 | ALDH1A1 (0.36) | KDM4EMAPTHTTALDH1A1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0629189-B1 | PREPARATION OF INTERMEDIATES IN THE SYNTHESIS OF QUINOLINE ANTIBIOTICS | PFIZER (US) | 1997-08-06 | — | — | EP | disclosed |
| US-5298629-A | Intermediates in the synthesis of quinoline antibiotics | PFIZER INC. (US) | 1994-03-29 | — | — | US | disclosed |
| US-5256791-A | Preparation of intermediates in the synthesis of quinoline antibiotics | PFIZER INC. (US) | 1993-10-26 | — | — | US | disclosed |