Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | EEF2K | O00418 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4251689 | 0.86 | P4HTM (0.55) | MAPTKMT2AMEN1LMNAHTT | |
| SCHEMBL8078603 | 0.85 | VNN1 (0.48) | EGFRMAPTKMT2AMEN1LMNA | |
| SCHEMBL8088414 | 0.83 | KMT2A (0.41) | MAPTKMT2AMEN1LMNAHTT | |
| SCHEMBL3643499 | 0.81 | P4HTM (0.50) | MAPTKMT2AMEN1ALDH1A1NPC1 | |
| SCHEMBL8071307 | 0.79 | MAPKAPK2 (0.46) | MAPTKMT2AMEN1LMNAHTT | |
| SCHEMBL8071311 | 0.78 | MEN1 (0.43) | MAPTKMT2AMEN1LMNAHTT | |
| SCHEMBL4247747 | 0.77 | P4HTM (0.53) | MAPTKMT2AMEN1ALDH1A1NPC1 | |
| SCHEMBL8082051 | 0.75 | HCAR3 (0.49) | EGFRMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL3646879 | 0.75 | EPHX1 (0.53) | MAPTALDH1A1NPC1RAB9AP4HTM | |
| SCHEMBL8081028 | 0.74 | HCAR3 (0.51) | MAPTKMT2AMEN1P4HTMEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009016088-A1 | THE USE OF BENZAMIDE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-02-05 | — | — | WO | disclosed |