Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | MGLL | Q99685 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.47 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5336468 | 0.87 | PTGS2 (0.60) | FAAHMGLLPTGS2AKR1C2AKR1C1 | |
| SCHEMBL5336464 | 0.87 | PTGS2 (0.60) | FAAHMGLLPTGS2AKR1C2AKR1C1 | |
| SCHEMBL5336461 | 0.87 | PTGS2 (0.60) | FAAHMGLLPTGS2AKR1C2AKR1C1 | |
| SCHEMBL8092899 | 0.84 | PTGS2 (0.57) | FAAHMGLLPTGS2AKR1C2AKR1C1 | |
| SCHEMBL7844135 | 0.75 | PTGS2 (0.57) | FAAHMGLLPTGS2AKR1C2AKR1C1 | |
| SCHEMBL4030635 | 0.74 | PTGS2 (0.62) | PTGS2AKR1C2AKR1C1AKR1C3ESR2 | |
| SCHEMBL6050635 | 0.74 | CES2 (0.64) | FAAHMGLLPTGS2AKR1C2AKR1C1 | |
| SCHEMBL7880898 | 0.74 | PTGS2 (0.50) | FAAHMGLLPTGS2AKR1C2AKR1C1 | |
| SCHEMBL7829898 | 0.74 | PTGS2 (0.50) | FAAHMGLLPTGS2AKR1C2AKR1C1 | |
| SCHEMBL8125071 | 0.74 | PTGS2 (0.50) | FAAHMGLLPTGS2AKR1C2AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882015-B1 | DIPHENYL STILBENES AS PRODRUGS TO COX-2 INHIBITORS | MERCK FROSST CANADA INC (CA) | 2000-12-27 | — | — | EP | claimed |
| US-5733909-A | ANTIINFLAMMATORY AGENTS; ANALGESICS; ANTIPYRETIC AGENT | MERCK FROSST CANADA, INC. (CA) | 1998-03-31 | — | — | US | claimed |
| EP-0882015-B1 | DIPHENYL STILBENES AS PRODRUGS TO COX-2 INHIBITORS | MERCK FROSST CANADA INC (CA) | 2000-12-27 | — | — | EP | disclosed |
| US-5733909-A | ANTIINFLAMMATORY AGENTS; ANALGESICS; ANTIPYRETIC AGENT | MERCK FROSST CANADA, INC. (CA) | 1998-03-31 | — | — | US | disclosed |