Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.60 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5336464 | 1.00 | PTGS2 (0.60) | PTGS2FAAHMGLLAKR1C2AKR1C1 | |
| SCHEMBL5336461 | 1.00 | PTGS2 (0.60) | PTGS2FAAHMGLLAKR1C2AKR1C1 | |
| SCHEMBL8084023 | 0.87 | FAAH (0.48) | PTGS2FAAHMGLLAKR1C2AKR1C1 | |
| SCHEMBL4957182 | 0.86 | TSHR (0.52) | — | |
| SCHEMBL5344331 | 0.84 | PTGS2 (0.68) | PTGS2AKR1C2AKR1C1AKR1C3 | |
| SCHEMBL5344336 | 0.84 | PTGS2 (0.68) | PTGS2AKR1C2AKR1C1AKR1C3 | |
| SCHEMBL5344325 | 0.84 | PTGS2 (0.68) | PTGS2AKR1C2AKR1C1AKR1C3 | |
| SCHEMBL8425841 | 0.80 | PTGS2 (0.50) | PTGS2 | |
| SCHEMBL14516354 | 0.80 | KMT2A (0.48) | AKR1C3 | |
| SCHEMBL14516363 | 0.77 | ESR2 (0.55) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882015-A1 | DIPHENYL STILBENES AS PRODRUGS TO COX-2 INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1998-12-09 | — | — | EP | claimed |
| WO-1997028120-A1 | DIPHENYL STILBENES AS PRODRUGS TO COX-2 INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1997-08-07 | — | — | WO | claimed |
| US-7199154-B2 | Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors | MERCK FROSST COMPANY (CA) | 2007-04-03 | — | — | US | disclosed |
| US-20050261245-A1 | Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors | MERCK FROSST COMPANY (CA) | 2005-11-24 | — | — | US | disclosed |
| EP-1527045-A1 | NITRIC OXIDE RELEASING PRODRUGS OF DIARYL-2-(5H)-FURANONES AS CYCLOOXYGENASE-2 INHIBITORS | Merck Frosst Canada & Co. (CA) | 2005-05-04 | — | — | EP | disclosed |
| WO-2004011421-A1 | NITRIC OXIDE RELEASING PRODRUGS OF DIARYL-2-(5H)-FURANONES AS CYCLOOXYGENASE-2 INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2004-02-05 | — | — | WO | disclosed |
| EP-0882015-B1 | DIPHENYL STILBENES AS PRODRUGS TO COX-2 INHIBITORS | MERCK FROSST CANADA INC (CA) | 2000-12-27 | — | — | EP | disclosed |
| EP-0882015-A1 | DIPHENYL STILBENES AS PRODRUGS TO COX-2 INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1998-12-09 | — | — | EP | disclosed |
| WO-1997028120-A1 | DIPHENYL STILBENES AS PRODRUGS TO COX-2 INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1997-08-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261245-A1 | Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors | PTGIS, PTGS1, PTGS2 | PTGS2 3/4885FAAH 400/4885MGLL 2587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.