Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.31 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 4/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8084219 | 0.86 | KDM4E (0.36) | CYP19A1MAOBKDM4EALDH1A1HPGD | |
| SCHEMBL8088499 | 0.85 | TP53 (0.34) | CYP19A1MAOBMAPTTDP1 | |
| SCHEMBL8084230 | 0.85 | HRH4 (0.30) | — | |
| SCHEMBL9796819 | 0.85 | HRH4 (0.34) | ALDH1A1HPGDTDP1 | |
| SCHEMBL8085076 | 0.85 | NPSR1 (0.34) | CYP19A1MALT1MAOBTRPV1MAPT | |
| SCHEMBL8077124 | 0.84 | PSEN1 (0.36) | HSD11B1TRPV1ALDH1A1 | |
| SCHEMBL8084378 | 0.84 | ATM (0.32) | MAPTALDH1A1HPGD | |
| SCHEMBL7266931 | 0.83 | RXFP1 (0.32) | ALDH1A1TDP1 | |
| SCHEMBL8085319 | 0.83 | PPIB (0.44) | CYP19A1MAOBMAPTKDM4EALDH1A1 | |
| SCHEMBL8085302 | 0.83 | ALDH1A1 (0.37) | MAPTKDM4EALDH1A1HPGDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |
| EP-0273262-A2 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1988-07-06 | — | — | EP | disclosed |