SCHEMBL8084418

SCHEMBL8084418

CC(CNC(C)(C)c1ccccc1)c1cccc2ccccc12

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 3/20 0.41
CASR P41180 5/20 0.40
ADRA2C P18825 3/20 0.40
SLC6A2 P23975 2/20 0.40
HTR2C P28335 2/20 0.40
OPRM1 P35372 2/20 0.40
DRD3 P35462 2/20 0.40
MLNR O43193 1/20 0.40
ABCB11 O95342 1/20 0.40
ADRB1 P08588 1/20 0.40
ADORA3 P0DMS8 1/20 0.40
CYP2D6 P10635 1/20 0.40
CHRM1 P11229 1/20 0.40
DRD2 P14416 1/20 0.40
CHRM3 P20309 1/20 0.40
GLRA1 P23415 1/20 0.40
AVPR2 P30518 1/20 0.40
HRH1 P35367 1/20 0.40
MC3R P41968 1/20 0.40
HTT P42858 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9667745 0.76 SLC6A4 (0.53) SLC6A4CASRSLC6A2ALDH1A1CYP1A2
SCHEMBL8084421 0.74 SLC6A4 (0.51) SLC6A4ALDH1A1CYP1A2CYP2C9CYP2C19
SCHEMBL8098965 0.73 SLC6A2 (0.46) SLC6A4CASRSLC6A2CYP2D6SLC6A3
SCHEMBL2349995 0.71 BACE1 (0.46) SLC6A4ADRB1CYP2D6ALDH1A1CYP1A2
SCHEMBL15211048 0.70 TSHR (0.55) SLC6A4CASRADRA2CADRA1BALDH1A1
SCHEMBL2127427 0.70 TSHR (0.55) SLC6A4CASRADRA2CADRA1BALDH1A1
SCHEMBL8100039 0.70 NQO2 (0.51) SLC6A4CASRSLC6A2CYP2D6KCNH2
SCHEMBL7723726 0.70 MTNR1A (0.50) HTR2COPRM1OPRK1ALDH1A1EPHX2
SCHEMBL4189468 0.69 ACP3 (0.55) SLC6A4SLC6A2CYP2D6SLC6A3SIGMAR1
SCHEMBL3412391 0.69 ALDH1A1 (0.50) SLC6A4ADRA2CADRA1BALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6057371-A TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION VIRGINIA COMMONWEALTH UNIVERSITY (US) 2000-05-02 US claimed
EP-0591426-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1994-04-13 EP claimed
WO-1993000313-A2 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1993-01-07 WO claimed
WO-1991009594-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1991-07-11 WO claimed
US-6057371-A TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION VIRGINIA COMMONWEALTH UNIVERSITY (US) 2000-05-02 US disclosed
EP-0591426-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1994-04-13 EP disclosed
EP-0507863-A4 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF 1993-07-07 EP disclosed
WO-1993000313-A2 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1993-01-07 WO disclosed
EP-0507863-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1992-10-14 EP disclosed
WO-1991009594-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1991-07-11 WO disclosed