SCHEMBL8098965

SCHEMBL8098965

CC(CNC(C)(C)c1ccccc1)c1ccc2ccccc2c1

nearest known ligand 0.47

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 11/20 0.46
SLC6A4 P31645 11/20 0.46
SLC6A3 Q01959 11/20 0.46
KCNH2 Q12809 10/20 0.46
CYP2D6 P10635 9/20 0.46
CYP3A4 P08684 7/20 0.46
MEN1 O00255 1/20 0.46
CYP1A2 P05177 1/20 0.46
TSHR P16473 1/20 0.46
KMT2A Q03164 1/20 0.46
HIF1A Q16665 1/20 0.46
UGT2B7 P16662 1/20 0.44
CASR P41180 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8098968 0.76 CYP2D6 (0.51) SLC6A2SLC6A4SLC6A3KCNH2CYP2D6
SCHEMBL9668424 0.76 SLC6A2 (0.59) SLC6A2SLC6A4SLC6A3KCNH2CYP2D6
SCHEMBL8084418 0.73 SLC6A4 (0.41) SLC6A2SLC6A4SLC6A3KCNH2CYP2D6
SCHEMBL23330351 0.73 UGT2B7 (0.55) SLC6A2SLC6A4SLC6A3KCNH2CYP2D6
SCHEMBL2349995 0.71 BACE1 (0.46) SLC6A4CYP2D6CYP1A2HIF1A
SCHEMBL16684715 0.70 UGT2B7 (0.59) CYP2D6MEN1CYP1A2TSHRKMT2A
SCHEMBL5401290 0.70 UGT2B7 (0.59) CYP2D6MEN1CYP1A2TSHRKMT2A
SCHEMBL8093077 0.70 CASR (0.49) CYP1A2CASR
SCHEMBL5877749 0.70 GRIA4 (0.61) SLC6A2SLC6A4SLC6A3KCNH2CYP2D6
SCHEMBL74874 0.69 UGT2B7 (0.57) SLC6A2SLC6A4SLC6A3KCNH2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6057371-A TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION VIRGINIA COMMONWEALTH UNIVERSITY (US) 2000-05-02 US claimed
EP-0591426-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1994-04-13 EP claimed
EP-0507863-A4 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF 1993-07-07 EP claimed
WO-1993000313-A2 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1993-01-07 WO claimed
EP-0507863-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1992-10-14 EP claimed
WO-1991009594-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1991-07-11 WO claimed
US-6057371-A TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION VIRGINIA COMMONWEALTH UNIVERSITY (US) 2000-05-02 US disclosed
EP-0591426-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1994-04-13 EP disclosed
WO-1993000313-A2 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1993-01-07 WO disclosed