Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15651246 | 0.81 | OPRK1 (0.43) | TSHRLMNAALDH1A1 | |
| SCHEMBL14958584 | 0.81 | TDP1 (0.57) | KMT2AEGFRERBB2LMNAALDH1A1 | |
| SCHEMBL12157433 | 0.81 | KMT2A (0.53) | KMT2AMEN1TSHR | |
| SCHEMBL3129879 | 0.79 | MEN1 (0.51) | KMT2AMEN1SIGMAR1SMN1; SMN2 | |
| SCHEMBL8437183 | 0.76 | SRD5A2 (0.64) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL467498 | 0.76 | KMT2A (0.56) | KMT2AMEN1SIGMAR1EGFRERBB2 | |
| SCHEMBL27614321 | 0.76 | KMT2A (0.49) | KMT2AMEN1SIGMAR1SMN1; SMN2 | |
| SCHEMBL8084456 | 0.75 | MMP1 (0.42) | KMT2AMEN1TSHRLMNAALDH1A1 | |
| SCHEMBL10137785 | 0.75 | KMT2A (0.51) | KMT2AMEN1EGFRERBB2EPHX1 | |
| SCHEMBL12002657 | 0.74 | MEN1 (0.48) | KMT2AMEN1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757982-B1 | Biphenylic compounds, process for their preparations and intermediates for this process, their use as 5-alpha-reductase inhibitors and pharmaceutical compositions containing them | HOECHST MARION ROUSSEL INC (FR) | 2000-09-20 | — | — | EP | disclosed |
| US-5965763-A | Biphenyl compounds | HOECHST MARION ROUSSEL (FR) | 1999-10-12 | — | — | US | disclosed |
| US-5827887-A | 5-ALPHA REDUCTASE INHIBITORS | ROUSSEL UCLAF (FR) | 1998-10-27 | — | — | US | disclosed |
| EP-0757982-A1 | Biphenylic compounds, process for their preparations and intermediates for this process, their use as 5-alpha-reductase inhibitors and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1997-02-12 | — | — | EP | disclosed |