Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 1.00 |
| ▸ | MAOB | P27338 | 2/20 | 0.59 |
| ▸ | MAOA | P21397 | 1/20 | 0.59 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.58 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.58 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.58 |
| ▸ | ACHE | P22303 | 4/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2949711 | 0.92 | SIGMAR1 (0.85) | SIGMAR1CARM1PRMT6PRMT8 | |
| SCHEMBL29733117 | 0.92 | SIGMAR1 (0.85) | SIGMAR1MAOBMAOACARM1PRMT6 | |
| SCHEMBL7225346 | 0.92 | SIGMAR1 (0.85) | SIGMAR1MAOBMAOACARM1PRMT6 | |
| SCHEMBL8096630 | 0.88 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL16260101 | 0.86 | SIGMAR1 (0.76) | SIGMAR1MAOBMAOACARM1PRMT6 | |
| SCHEMBL7371550 | 0.86 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL11133953 | 0.86 | SIGMAR1 (0.96) | SIGMAR1 | |
| SCHEMBL1088446 | 0.86 | SIGMAR1 (0.74) | SIGMAR1MAOBMAOACARM1PRMT6 | |
| SCHEMBL25242768 | 0.85 | SIGMAR1 (0.79) | SIGMAR1 | |
| SCHEMBL11040881 | 0.85 | SIGMAR1 (0.73) | SIGMAR1MAOBMAOACARM1PRMT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057371-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2000-05-02 | — | — | US | claimed |
| EP-0591426-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-04-13 | — | — | EP | claimed |
| WO-1993000313-A2 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1993-01-07 | — | — | WO | claimed |
| US-6057371-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2000-05-02 | — | — | US | disclosed |
| EP-0591426-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-04-13 | — | — | EP | disclosed |
| WO-1993000313-A2 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1993-01-07 | — | — | WO | disclosed |