SCHEMBL8084830

SCHEMBL8084830

O=C(Cl)c1cnc2cc3c(cc2c1Cl)OCO3

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.53
LMNA P02545 7/20 0.53
SMN1; SMN2 Q16637 6/20 0.53
HPGD P15428 6/20 0.53
HTT P42858 5/20 0.53
MAPT P10636 3/20 0.53
NPSR1 Q6W5P4 2/20 0.47
KDM4E B2RXH2 3/20 0.37
ATM Q13315 1/20 0.36
KMT2A Q03164 1/20 0.36
TP53 P04637 2/20 0.35
GAA P10253 1/20 0.35
MPO P05164 1/20 0.35
NPC1 O15118 2/20 0.34
RAB9A P51151 2/20 0.34
TDP1 Q9NUW8 1/20 0.34
PI4K2A Q9BTU6 1/20 0.34
CYP1A2 P05177 1/20 0.34
HIF1A Q16665 1/20 0.34
PDE5A O76074 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5929756 0.88 ALDH1A1 (0.53) ALDH1A1LMNASMN1; SMN2HPGDHTT
SCHEMBL6108099 0.80 ALDH1A1 (0.49) ALDH1A1LMNASMN1; SMN2HPGDHTT
SCHEMBL5929729 0.80 ALDH1A1 (0.52) ALDH1A1LMNASMN1; SMN2HPGDHTT
SCHEMBL6085438 0.76 RAB9A (0.52) ALDH1A1LMNASMN1; SMN2HPGDHTT
SCHEMBL13163268 0.75 SMN1; SMN2 (0.44) ALDH1A1LMNASMN1; SMN2HPGDHTT
SCHEMBL13993584 0.75 LMNA (0.42) ALDH1A1LMNASMN1; SMN2HPGDHTT
SCHEMBL13163262 0.75 SMN1; SMN2 (0.40) ALDH1A1LMNASMN1; SMN2HPGDHTT
SCHEMBL241594 0.75 ALDH1A1 (0.48) ALDH1A1LMNASMN1; SMN2HPGDHTT
SCHEMBL8089093 0.73 ALDH1A1 (0.47) ALDH1A1LMNASMN1; SMN2HPGDHTT
Hydrochloric Acid SCHEMBL6084714 0.73 ALDH1A1 (0.47) ALDH1A1LMNASMN1; SMN2HPGDHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6133270-A Isothiazolones and pharmaceutical formulations WARNER-LAMBERT COMPANY (US) 2000-10-17 US disclosed
US-6001863-A USEFUL AS ANTIVIRAL, ANTIINFLAMMATORY AND ANTIATHEROSCLEROSIS AGENT; ADMINISTERING TO THE PATIENT IN NEED OF ZINC EJECTION FROM NUCLEOCAPSID PROTEIN WARNER-LAMBERT COMPANY (US) 1999-12-14 US disclosed
EP-0828488-A1 ISOTHIAZOLONES WARNER-LAMBERT COMPANY (US) 1998-03-18 EP disclosed
US-5668162-A Isothiazolones lower plasma levels of lipoprotein(a) WARNER-LAMBERT COMPANY 1997-09-16 US disclosed
US-5620997-A VIRICIDES, ANTIINFLAMMATORY AGENTS, ANTIATHEROSCLEROTIC AGENT WARNER-LAMBERT COMPANY (US) 1997-04-15 US disclosed
WO-1996038144-A1 ISOTHIAZOLONES WARNER-LAMBERT COMPANY (US) 1996-12-05 WO disclosed