Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8084419 | 0.89 | CFTR (0.38) | CFTRSMN1; SMN2CYP19A1GAACYP1A2 | |
| SCHEMBL8090476 | 0.85 | SMN1; SMN2 (0.38) | CFTRSMN1; SMN2GAACYP1A2ALDH1A1 | |
| SCHEMBL8084289 | 0.85 | CFTR (0.41) | CFTRSMN1; SMN2CYP19A1GAACYP1A2 | |
| SCHEMBL8085303 | 0.84 | CHRM2 (0.34) | ALDH1A1KMT2ATDP1 | |
| SCHEMBL8085257 | 0.83 | MEN1 (0.34) | ALDH1A1KMT2ATDP1 | |
| SCHEMBL8077310 | 0.83 | PDE4A (0.37) | CYP1A2KDM4EKMT2ADYRK1A | |
| SCHEMBL8085097 | 0.83 | CFTR (0.38) | CFTRSMN1; SMN2CYP19A1GAACYP1A2 | |
| SCHEMBL8085225 | 0.82 | TDP1 (0.36) | CYP1A2HTTALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL8088667 | 0.81 | KMT2A (0.42) | CFTRSMN1; SMN2GAACYP1A2ALDH1A1 | |
| SCHEMBL7373225 | 0.81 | CCNC (0.32) | DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |
| EP-0273262-A2 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1988-07-06 | — | — | EP | disclosed |