Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.31 |
| ▸ | ABCC9 | O60706 | 5/20 | 0.31 |
| ▸ | DRD2 | P14416 | 3/20 | 0.31 |
| ▸ | DRD3 | P35462 | 3/20 | 0.31 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.31 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8088696 | 0.89 | PDE4A (0.37) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL8085352 | 0.85 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL8090750 | 0.85 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL8085129 | 0.84 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL8084934 | 0.83 | CFTR (0.38) | KDM4ECYP1A2KMT2ADYRK1A | |
| SCHEMBL8084925 | 0.83 | EGLN2 (0.33) | KDM4EGPR35ABCC9DRD2DRD3 | |
| SCHEMBL9378613 | 0.83 | ABCC9 (0.33) | KDM4EGPR35ABCC9DRD2DRD3 | |
| SCHEMBL8077281 | 0.82 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL8090684 | 0.81 | EGLN2 (0.38) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL9733641 | 0.81 | OTUD7B (0.31) | DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |