Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | RORC | P51449 | 6/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8085097 | 0.85 | CFTR (0.38) | CFTRSMN1; SMN2CYP19A1HTTCYP1A2 | |
| SCHEMBL8084420 | 0.85 | CFTR (0.38) | CFTRSMN1; SMN2RORCCYP19A1MAPT | |
| SCHEMBL8084426 | 0.84 | ALDH1A1 (0.36) | MEN1KMT2AALDH1A1 | |
| SCHEMBL8088675 | 0.84 | RECQL (0.44) | SMN1; SMN2MAPTHTTLMNAMAOB | |
| SCHEMBL8090492 | 0.83 | KDM4E (0.36) | MAPTHTTMAOBMEN1PKM | |
| SCHEMBL8077334 | 0.83 | ALDH1A1 (0.38) | MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL8085335 | 0.83 | ABCC9 (0.35) | SMN1; SMN2MAPTGAAMEN1PKM | |
| SCHEMBL8076907 | 0.82 | TDP1 (0.37) | CFTRHTTMEN1KMT2AALDH1A1 | |
| SCHEMBL8077303 | 0.82 | ALDH1A1 (0.36) | SMN1; SMN2GAAMEN1KMT2AALDH1A1 | |
| SCHEMBL8084289 | 0.82 | CFTR (0.41) | CFTRSMN1; SMN2RORCCYP19A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |
| US-5013853-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1991-05-07 | — | — | US | disclosed |
| EP-0340718-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1989-11-08 | — | — | EP | disclosed |