Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PTPRC | P08575 | 3/20 | 0.33 |
| ▸ | S100A4 | P26447 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | CASP4 | P49662 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8084426 | 0.88 | ALDH1A1 (0.36) | ALDH1A1MEN1KMT2AMALT1CYP3A4 | |
| SCHEMBL8077303 | 0.88 | ALDH1A1 (0.36) | ALDH1A1MEN1KMT2AMALT1GABRA1 | |
| SCHEMBL8076907 | 0.88 | TDP1 (0.37) | ALDH1A1MEN1KMT2AMALT1CYP3A4 | |
| SCHEMBL8076882 | 0.87 | ABCC9 (0.37) | POLBMEN1KMT2AMALT1TDP1 | |
| SCHEMBL8085347 | 0.86 | ADORA3 (0.36) | ALDH1A1MEN1KMT2ACYP3A4TDP1 | |
| SCHEMBL8076960 | 0.86 | MEN1 (0.37) | ALDH1A1POLBMEN1KMT2ACTDSP1 | |
| SCHEMBL8090492 | 0.85 | KDM4E (0.36) | ALDH1A1POLBMEN1KMT2AMALT1 | |
| SCHEMBL8085346 | 0.84 | ALDH1A1 (0.38) | ALDH1A1POLBMEN1KMT2AMALT1 | |
| SCHEMBL8088847 | 0.84 | MYC (0.38) | ALDH1A1POLBMEN1KMT2ACYP3A4 | |
| SCHEMBL8088675 | 0.84 | RECQL (0.44) | ALDH1A1POLBMEN1KMT2AMALT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |
| US-5013853-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1991-05-07 | — | — | US | disclosed |