Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8081438 | 0.90 | PTGS2 (0.36) | KDM4EALDH1A1HPGDATMPDE1A | |
| SCHEMBL8085222 | 0.86 | KDM4E (0.40) | KDM4EALDH1A1HPGDMAPTHSD17B10 | |
| SCHEMBL8085193 | 0.82 | ALOX5 (0.48) | KDM4EALDH1A1HPGDMAPTHSD17B10 | |
| SCHEMBL8085093 | 0.81 | KDM4E (0.43) | KDM4EALDH1A1HPGDPDE1APDE1B | |
| SCHEMBL8081905 | 0.76 | ALOX5 (0.45) | KDM4EALDH1A1HPGDMAPK1ALOX5 | |
| SCHEMBL8086814 | 0.74 | ALOX5 (0.55) | KDM4EALDH1A1HPGDMAPTHSD17B10 | |
| SCHEMBL8080596 | 0.74 | PTGS2 (0.42) | KDM4EALDH1A1HPGDATMMAPT | |
| SCHEMBL8080528 | 0.74 | PTGS2 (0.41) | KDM4EALDH1A1HPGDATMPDE1A | |
| SCHEMBL8081514 | 0.72 | TARBP2 (0.43) | KDM4EALDH1A1HPGDPDE1APDE1B | |
| SCHEMBL2952186 | 0.71 | PRKCI (0.52) | KDM4EALDH1A1HPGDMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |