Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TARBP2 | Q15633 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | GCGR | P47871 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 3/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8081438 | 0.85 | PTGS2 (0.36) | PTGS2ALDH1A1HPGDKDM4EATM | |
| SCHEMBL8081363 | 0.85 | PTGS2 (0.44) | PTGS2ALDH1A1HPGDKDM4ECASP3 | |
| SCHEMBL8080528 | 0.84 | PTGS2 (0.41) | PTGS2ALDH1A1HPGDKDM4EATM | |
| SCHEMBL8081344 | 0.78 | PTGS2 (0.42) | PTGS2ALDH1A1HPGDKDM4ETARBP2 | |
| SCHEMBL8081346 | 0.78 | NPC1 (0.48) | ALDH1A1HPGDKDM4EATMTARBP2 | |
| SCHEMBL8072887 | 0.76 | PTGS2 (0.43) | PTGS2ALDH1A1KDM4ENPC1CASP3 | |
| SCHEMBL8467959 | 0.76 | PTGS2 (0.42) | PTGS2ALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL8072765 | 0.75 | PTGS2 (0.45) | PTGS2ALDH1A1HPGDNPC1GCGR | |
| SCHEMBL9860617 | 0.74 | SLC10A2 (0.48) | ALDH1A1HPGDKDM4ETARBP2LMNA | |
| SCHEMBL8085133 | 0.74 | KDM4E (0.41) | ALDH1A1HPGDKDM4EATMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |