Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 6/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.50 |
| ▸ | MTOR | P42345 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MOK | Q9UQ07 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8095869 | 0.89 | PIK3CA (0.46) | PIK3CDPIK3CAMTORALDH1A1HPGD | |
| SCHEMBL8093349 | 0.86 | PIK3CD (0.48) | PIK3CDPIK3CAMTORALDH1A1HPGD | |
| SCHEMBL8101524 | 0.86 | MEN1 (0.54) | PIK3CDPIK3CAMTORALDH1A1HPGD | |
| SCHEMBL8101525 | 0.84 | TP53 (0.51) | PIK3CDPIK3CAMTORALDH1A1HPGD | |
| SCHEMBL11925797 | 0.84 | PIK3CA (0.49) | PIK3CDPIK3CAMTORALDH1A1HPGD | |
| SCHEMBL8104034 | 0.83 | MAPT (0.49) | PIK3CDPIK3CAMTORALDH1A1HPGD | |
| SCHEMBL8106035 | 0.83 | PTPN1 (0.52) | PIK3CDPIK3CAMTORALDH1A1HPGD | |
| SCHEMBL8103957 | 0.83 | PIK3CD (0.47) | PIK3CDPIK3CAMTORALDH1A1HPGD | |
| SCHEMBL8106107 | 0.83 | CA12 (0.49) | PIK3CDPIK3CAMTORALDH1A1HPGD | |
| SCHEMBL8103980 | 0.83 | PIK3CA (0.47) | PIK3CDPIK3CAMTORALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007749-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |