Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 17/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8092804 | 0.86 | MAPK13 (0.59) | PTGS2PTGS1MAPK13MAPK12MAPK11 | |
| SCHEMBL8101120 | 0.84 | ALDH1A1 (0.51) | PTGS2PTGS1MAPK13MAPK12MAPK11 | |
| SCHEMBL8095114 | 0.84 | PTGS2 (0.58) | PTGS2PTGS1 | |
| SCHEMBL8101739 | 0.83 | MAPK13 (0.54) | PTGS2PTGS1MAPK13MAPK12MAPK11 | |
| SCHEMBL8087346 | 0.83 | MAPK13 (0.48) | PTGS2PTGS1MAPK13MAPK12MAPK11 | |
| SCHEMBL8093657 | 0.83 | PTGS2 (0.56) | PTGS2PTGS1 | |
| SCHEMBL215180 | 0.82 | PTGS2 (0.54) | PTGS2PTGS1 | |
| SCHEMBL8085735 | 0.82 | PTGS2 (0.52) | PTGS2PTGS1MAPK13MAPK12MAPK11 | |
| SCHEMBL8095596 | 0.82 | PTGS2 (0.46) | PTGS2PTGS1MAPK13MAPK12MAPK11 | |
| SCHEMBL8092688 | 0.81 | MAPK13 (0.43) | PTGS2PTGS1MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808304-B1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2000-12-27 | — | — | EP | claimed |
| EP-0808304-B1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2000-12-27 | — | — | EP | disclosed |
| US-5916905-A | ANTIARTHRITIC AGENTS; ANALGESICS; ANTIPYRETICS | G. D. SEARLE & CO. (US) | 1999-06-29 | — | — | US | disclosed |
| EP-0808304-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-11-26 | — | — | EP | disclosed |
| US-5686470-A | 2, 3-substituted pyridines for the treatment of inflammation | WEIER RICHARD M (US) | 1997-11-11 | — | — | US | disclosed |
| WO-1996024584-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-15 | — | — | WO | disclosed |