Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 17/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8093245 | 0.90 | ALDH1A1 (0.45) | PTGS2PTGS1ALDH1A1LMNACNR1 | |
| SCHEMBL8092804 | 0.86 | MAPK13 (0.59) | PTGS2PTGS1MAPK13MAPK12MAPK11 | |
| SCHEMBL8085735 | 0.84 | PTGS2 (0.52) | PTGS2PTGS1MAPK13MAPK12MAPK11 | |
| SCHEMBL8086624 | 0.82 | PTGS2 (0.56) | PTGS2PTGS1MAPK13MAPK12MAPK11 | |
| SCHEMBL8099590 | 0.82 | PTGS2 (0.54) | PTGS2PTGS1MAPK13MAPK12MAPK11 | |
| SCHEMBL8095119 | 0.81 | HPGD (0.47) | PTGS2PTGS1ALDH1A1LMNA | |
| SCHEMBL8085292 | 0.81 | PTGS2 (0.52) | PTGS2PTGS1MAPK13MAPK12MAPK11 | |
| SCHEMBL8086508 | 0.81 | PTGS2 (0.60) | PTGS2PTGS1ALDH1A1LMNA | |
| SCHEMBL8094759 | 0.81 | PTGS2 (0.55) | PTGS2PTGS1MAPK13MAPK12MAPK11 | |
| SCHEMBL8095222 | 0.81 | PTGS2 (0.53) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808304-B1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2000-12-27 | — | — | EP | disclosed |
| US-5916905-A | ANTIARTHRITIC AGENTS; ANALGESICS; ANTIPYRETICS | G. D. SEARLE & CO. (US) | 1999-06-29 | — | — | US | disclosed |
| EP-0808304-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-11-26 | — | — | EP | disclosed |
| US-5686470-A | 2, 3-substituted pyridines for the treatment of inflammation | WEIER RICHARD M (US) | 1997-11-11 | — | — | US | disclosed |
| WO-1996024584-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-15 | — | — | WO | disclosed |