Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8087155 | 0.80 | AKR1B1 (0.42) | ALDH1A1LMNAHTTTSHRCA12 | |
| SCHEMBL3663637 | 0.73 | HSD17B10 (0.43) | HSD17B10SMN1; SMN2ALDH1A1LMNAHSP90AA1 | |
| SCHEMBL3703857 | 0.70 | SMN1; SMN2 (0.42) | HSD17B10SMN1; SMN2ALDH1A1PKMCYP1A2 | |
| SCHEMBL31686158 | 0.70 | SMN1; SMN2 (0.42) | HSD17B10SMN1; SMN2ALDH1A1PKMCYP1A2 | |
| SCHEMBL68340 | 0.69 | PKM (0.60) | HSD17B10SMN1; SMN2ALDH1A1LMNAPKM | |
| SCHEMBL12602244 | 0.68 | ALDH1A1 (0.43) | HSD17B10ALDH1A1MAPTHTTPKM | |
| SCHEMBL7403188 | 0.68 | KDM4E (0.47) | SMN1; SMN2ALDH1A1PKM | |
| SCHEMBL1873977 | 0.68 | ALDH1A1 (0.68) | SMN1; SMN2ALDH1A1LMNAMAPTPKM | |
| SCHEMBL112999 | 0.68 | ALDH1A1 (0.68) | SMN1; SMN2ALDH1A1LMNAMAPTPKM | |
| SCHEMBL1332625 | 0.68 | ALDH1A1 (0.68) | SMN1; SMN2ALDH1A1LMNAMAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080743-A | AS CHEMICAL INTERMEIDATES FOR PREPARING DRUGS | NOVARTIS AG (CH) | 2000-06-27 | — | — | US | disclosed |
| EP-0853617-A1 | NOVEL 2,3-DIOXO-1,2,3,4-TETRAHYDRO-QUINOYXALINYL DERIVATIVES | Novartis AG (CH) | 1998-07-22 | — | — | EP | disclosed |
| WO-1997008155-A1 | NOVEL 2,3-DIOXO-1,2,3,4-TETRAHYDRO-QUINOYXALINYL DERIVATIVES | NOVARTIS AG (CH) | 1997-03-06 | — | — | WO | disclosed |