SCHEMBL8088656

SCHEMBL8088656

COC(=O)Cc1ccc(OCc2ccccc2)cc1OCC(F)(F)F

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MRGPRX4 Q96LA9 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.46
CYP1A2 P05177 1/20 0.45
CYP2C9 P11712 1/20 0.45
PPARA Q07869 2/20 0.44
ALDH1A1 P00352 2/20 0.44
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
MAOB P27338 2/20 0.43
GAA P10253 1/20 0.43
MAPT P10636 1/20 0.43
XBP1 P17861 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
PDK1 Q15118 1/20 0.43
PDK2 Q15119 1/20 0.43
PDK3 Q15120 1/20 0.43
PDK4 Q16654 1/20 0.43
PPARG P37231 1/20 0.43
PPARD Q03181 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5446276 0.89 L3MBTL1 (0.53) L3MBTL1PPARAALDH1A1NPC1RAB9A
SCHEMBL8092952 0.83 CYP1A2 (0.48) CYP1A2CYP2C9PPARAALDH1A1RAB9A
SCHEMBL20954694 0.83 MTNR1A (0.48) MRGPRX4L3MBTL1PPARAALDH1A1NPC1
SCHEMBL20954700 0.83 MTNR1A (0.58) L3MBTL1CYP1A2CYP2C9PPARAALDH1A1
SCHEMBL6247717 0.83 MAOB (0.60) L3MBTL1CYP2C9PPARANPC1RAB9A
SCHEMBL31032329 0.82 RXRA (0.57) MRGPRX4PPARGPPARD
SCHEMBL20954710 0.81 MTNR1A (0.47) L3MBTL1PPARAALDH1A1NPC1RAB9A
SCHEMBL20954703 0.81 MEN1 (0.51) L3MBTL1PPARAALDH1A1NPC1PPARG
SCHEMBL1593105 0.81 MEN1 (0.51) MRGPRX4ALDH1A1NPC1RAB9ASMN1; SMN2
SCHEMBL29593701 0.81 MAOB (0.50) MRGPRX4L3MBTL1ALDH1A1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6090805-A Tocolytic oxytocin receptor antagonists MERCK & CO., INC. (US) 2000-07-18 US disclosed