Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 8/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.32 |
| ▸ | TYMS | P04818 | 1/20 | 0.32 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.31 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.31 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8090777 | 0.89 | PDE4A (0.38) | ABCC9MALT1PDE4APDE4BPDE4C | |
| SCHEMBL8077117 | 0.86 | ABCC9 (0.36) | ABCC9MALT1KDM4EABCB1ABCC8 | |
| SCHEMBL8076917 | 0.85 | ABCC9 (0.38) | ABCC9MALT1MAOBKDM4EABCB1 | |
| SCHEMBL8085335 | 0.84 | ABCC9 (0.35) | ABCC9MALT1KDM4E | |
| SCHEMBL7268194 | 0.83 | ABCC9 (0.36) | ABCC9MALT1PDE4APDE4BPDE4C | |
| SCHEMBL8090488 | 0.83 | ABCC9 (0.36) | ABCC9MALT1ABCB1 | |
| SCHEMBL8088675 | 0.83 | RECQL (0.44) | MALT1MAOBKDM4ETYMS | |
| SCHEMBL8076968 | 0.82 | MALT1 (0.35) | ABCC9MALT1MAOBKDM4EPDE4A | |
| SCHEMBL7274143 | 0.82 | PDE4A (0.42) | ABCC9MALT1MAOBKDM4EPDE4A | |
| SCHEMBL9379748 | 0.82 | ABCC9 (0.35) | ABCC9MALT1MAOBKDM4EPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5013853-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1991-05-07 | — | — | US | disclosed |