Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | ICMT | O60725 | 2/20 | 0.37 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | ABCC9 | O60706 | 3/20 | 0.35 |
| ▸ | BRD4 | O60885 | 3/20 | 0.33 |
| ▸ | BRD9 | Q9H8M2 | 3/20 | 0.33 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | STK10 | O94804 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | BRPF1 | P55201 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8088855 | 0.89 | ABCC9 (0.35) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL8076917 | 0.85 | ABCC9 (0.38) | ABCC9MALT1 | |
| SCHEMBL7268194 | 0.85 | ABCC9 (0.36) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL8090488 | 0.85 | ABCC9 (0.36) | ICMTABCC9MALT1 | |
| SCHEMBL8077117 | 0.83 | ABCC9 (0.36) | ABCC9MALT1 | |
| SCHEMBL8076882 | 0.82 | ABCC9 (0.37) | ARABCC9MALT1MEN1KMT2A | |
| SCHEMBL7277508 | 0.82 | ABCC9 (0.34) | ABCC9MALT1 | |
| SCHEMBL7267575 | 0.82 | ABCC9 (0.37) | ABCC9MALT1 | |
| SCHEMBL8085347 | 0.82 | ADORA3 (0.36) | MEN1KMT2A | |
| SCHEMBL8085126 | 0.81 | HTR1A (0.37) | PDE4APDE4BPDE4CPDE4DICMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |
| US-5013853-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1991-05-07 | — | — | US | disclosed |