Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.36 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.36 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8090277 | 0.85 | ABCC9 (0.49) | ABCC9KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL8085148 | 0.85 | ABCC9 (0.42) | ABCC9MAPTALDH1A1SMN1; SMN2GAA | |
| SCHEMBL7269286 | 0.83 | KMT2A (0.38) | KMT2AMEN1VCAM1MAPTALDH1A1 | |
| SCHEMBL7269439 | 0.81 | ABCC9 (0.44) | ABCC9LMNACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL7267316 | 0.81 | ABCC9 (0.59) | ABCC9LMNACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL7291313 | 0.78 | ABCC9 (0.54) | ABCC9KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL8088872 | 0.77 | ABCC9 (0.47) | ABCC9KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL10697493 | 0.77 | ABCC9 (0.40) | ABCC9KMT2AMEN1MAPTLMNA | |
| SCHEMBL8090116 | 0.76 | ABCC9 (0.46) | ABCC9LMNACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL10695898 | 0.75 | ABCC9 (0.49) | ABCC9LMNACYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |
| EP-0273262-A2 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1988-07-06 | — | — | EP | disclosed |