Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA7 | P43166 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8096816 | 0.89 | ALDH1A1 (0.45) | ALDH1A1CA12CA7CA9CA14 | |
| SCHEMBL8088373 | 0.89 | CA12 (0.52) | ALDH1A1CA12CA7CA9CA14 | |
| SCHEMBL8129039 | 0.89 | CA12 (0.56) | ALDH1A1CA12CA7CA9CA14 | |
| SCHEMBL8103411 | 0.81 | CA12 (0.41) | ALDH1A1CA12CA7CA9CA14 | |
| SCHEMBL8097774 | 0.80 | HPGD (0.38) | ALDH1A1CA12CA7CA9CA14 | |
| SCHEMBL8101293 | 0.76 | L3MBTL1 (0.49) | ALDH1A1CA12CA7CA9CA14 | |
| SCHEMBL8097211 | 0.74 | CA12 (0.42) | ALDH1A1CA12CA7CA9CA14 | |
| SCHEMBL5187860 | 0.74 | CA12 (0.53) | ALDH1A1CA12CA7CA9CA14 | |
| SCHEMBL2569441 | 0.73 | L3MBTL1 (0.55) | ALDH1A1L3MBTL1KMT2ALMNA | |
| SCHEMBL27373395 | 0.72 | HDAC3 (0.47) | ALDH1A1CA12CA7CA9CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080869-A | Benzothiazolone derivatives | ASTRA PHARMACEUTICALS LIMITED (GB) | 2000-06-27 | — | — | US | disclosed |
| EP-0850232-B1 | BENZOTHIAZOLONE DERIVATIVES | ASTRA PHARMA PROD (GB) | 2000-03-15 | — | — | EP | disclosed |
| US-6008365-A | ADRENORECEPTOR AGONISTS AND DOPAMINE DA2-RECEPTOR AGONISTS, USEFUL IN THE TREATMENT OF OBSTRUCTIVE AIRWAY DISEASES | ASTRA PHARMACEUTICALS LTD. (GB) | 1999-12-28 | — | — | US | disclosed |
| US-5977384-A | Benzothiazolone derivatives | ASTRA PHARMACEUTICALS LTD. (GB) | 1999-11-02 | — | — | US | disclosed |
| US-5973167-A | Intermediates for making benzothiazolone derivatives | ASTRA PHARMACEUTICALS LTD. (GB) | 1999-10-26 | — | — | US | disclosed |
| EP-0850232-A1 | BENZOTHIAZOLONE DERIVATIVES | Astra Pharmaceuticals Limited (GB) | 1998-07-01 | — | — | EP | disclosed |
| WO-1997010227-A1 | BENZOTHIAZOLONE DERIVATIVES | ASTRA PHARMACEUTICALS LIMITED (GB) | 1997-03-20 | — | — | WO | disclosed |