Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 5/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.36 |
| ▸ | CA7 | P43166 | 4/20 | 0.36 |
| ▸ | CA9 | Q16790 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 2/20 | 0.35 |
| ▸ | MMP12 | P39900 | 2/20 | 0.35 |
| ▸ | MMP13 | P45452 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | APLNR | P35414 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8088959 | 0.80 | ALDH1A1 (0.46) | CA12CA14CA7CA9L3MBTL1 | |
| SCHEMBL8129039 | 0.78 | CA12 (0.56) | HPGDCA12CA14CA7CA9 | |
| SCHEMBL8103411 | 0.78 | CA12 (0.41) | HPGDCA12CA14CA7CA9 | |
| SCHEMBL8088373 | 0.76 | CA12 (0.52) | HPGDCA12CA14CA7CA9 | |
| SCHEMBL8096816 | 0.76 | ALDH1A1 (0.45) | CA12CA14CA7CA9ALDH1A1 | |
| SCHEMBL9372873 | 0.75 | RPS6KB2 (0.52) | HPGDRPS6KB2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14049763 | 0.72 | MMP8 (0.46) | NPC1RAB9ASMN1; SMN2L3MBTL1MMP8 | |
| SCHEMBL8097211 | 0.71 | CA12 (0.42) | HPGDCA12CA14CA7CA9 | |
| SCHEMBL8097361 | 0.68 | CA12 (0.50) | HPGDCA12CA14CA7CA9 | |
| SCHEMBL8101407 | 0.67 | NPC1 (0.40) | NPC1RAB9ASMN1; SMN2L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080869-A | Benzothiazolone derivatives | ASTRA PHARMACEUTICALS LIMITED (GB) | 2000-06-27 | — | — | US | disclosed |
| EP-0850232-B1 | BENZOTHIAZOLONE DERIVATIVES | ASTRA PHARMA PROD (GB) | 2000-03-15 | — | — | EP | disclosed |
| US-6008365-A | ADRENORECEPTOR AGONISTS AND DOPAMINE DA2-RECEPTOR AGONISTS, USEFUL IN THE TREATMENT OF OBSTRUCTIVE AIRWAY DISEASES | ASTRA PHARMACEUTICALS LTD. (GB) | 1999-12-28 | — | — | US | disclosed |
| US-5977384-A | Benzothiazolone derivatives | ASTRA PHARMACEUTICALS LTD. (GB) | 1999-11-02 | — | — | US | disclosed |
| US-5973167-A | Intermediates for making benzothiazolone derivatives | ASTRA PHARMACEUTICALS LTD. (GB) | 1999-10-26 | — | — | US | disclosed |