Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGB1 | P09429 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mivazerol SCHEMBL593708 | 0.86 | PARP1 (0.39) | HMGB1 | |
| Mivazerol SCHEMBL8097939 | 0.86 | PARP1 (0.39) | HMGB1 | |
| SCHEMBL9132003 | 0.85 | — | — | |
| Mivazerol SCHEMBL8865135 | 0.85 | PARP1 (0.38) | HMGB1 | |
| SCHEMBL8095569 | 0.84 | — | — | |
| SCHEMBL8088784 | 0.84 | LMNA (0.31) | HMGB1 | |
| SCHEMBL8088780 | 0.84 | — | — | |
| SCHEMBL8095573 | 0.83 | — | — | |
| SCHEMBL9127794 | 0.83 | — | — | |
| SCHEMBL9647479 | 0.82 | P2RX7 (0.39) | HMGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626372-B1 | 2-hydroxy-3-[1-(1H-imidazol-4-yl)alkyl]benzenecarboximid-amides for the treatment of glaucoma | UCB SA (BE) | 2000-12-20 | — | — | EP | claimed |
| US-5385927-A | Hydroxy-3-[1-(1H-imidazol-4-yl)alkyl]-benzenecarboximidamides and their use in treating glaucoma | U C B, S.A. (BE) | 1995-01-31 | — | — | US | claimed |
| EP-0626372-A1 | 2-hydroxy-3- 1-(1H-imidazol-4-yl)alkyl benzenecarboximid-amides for the treatment of glaucoma | U C B, S.A. (BE) | 1994-11-30 | — | — | EP | claimed |
| JP-7070082-A | — | — | None | — | — | JP | disclosed |
| EP-0626372-B1 | 2-hydroxy-3-[1-(1H-imidazol-4-yl)alkyl]benzenecarboximid-amides for the treatment of glaucoma | UCB SA (BE) | 2000-12-20 | — | — | EP | disclosed |
| JP-H0770082-A | 2-HYDROXY-3-(1-(1H-IMIDAZOL-4-YL) ALKYL)BENZENECARBOXIMIDAMIDE | UCB SA | 1995-03-14 | — | — | JP | disclosed |
| US-5385927-A | Hydroxy-3-[1-(1H-imidazol-4-yl)alkyl]-benzenecarboximidamides and their use in treating glaucoma | U C B, S.A. (BE) | 1995-01-31 | — | — | US | disclosed |
| EP-0626372-A1 | 2-hydroxy-3- 1-(1H-imidazol-4-yl)alkyl benzenecarboximid-amides for the treatment of glaucoma | U C B, S.A. (BE) | 1994-11-30 | — | — | EP | disclosed |