Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 7/20 | 0.39 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 5/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mivazerol SCHEMBL593708 | 1.00 | PARP1 (0.39) | PARP1HMGB1MEN1KMT2AKDM4E | |
| Mivazerol SCHEMBL8865135 | 0.99 | PARP1 (0.38) | PARP1HMGB1MEN1KMT2AKDM4E | |
| SCHEMBL9647479 | 0.88 | P2RX7 (0.39) | HMGB1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL9518487 | 0.87 | HMGB1 (0.48) | HMGB1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL4759339 | 0.87 | PARP1 (0.39) | PARP1MEN1KMT2AKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL10401999 | 0.86 | HMGB1 (0.47) | HMGB1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL8089240 | 0.86 | HMGB1 (0.31) | HMGB1 | |
| SCHEMBL9645443 | 0.85 | MPO (0.38) | HMGB1KDM4E | |
| SCHEMBL9647526 | 0.85 | PLK1 (0.38) | HMGB1KDM4EALDH1A1HPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL10402113 | 0.84 | MPO (0.37) | HMGB1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626372-B1 | 2-hydroxy-3-[1-(1H-imidazol-4-yl)alkyl]benzenecarboximid-amides for the treatment of glaucoma | UCB SA (BE) | 2000-12-20 | — | — | EP | claimed |
| EP-0626372-B1 | 2-hydroxy-3-[1-(1H-imidazol-4-yl)alkyl]benzenecarboximid-amides for the treatment of glaucoma | UCB SA (BE) | 2000-12-20 | — | — | EP | disclosed |
| EP-0626372-A1 | 2-hydroxy-3- 1-(1H-imidazol-4-yl)alkyl benzenecarboximid-amides for the treatment of glaucoma | U C B, S.A. (BE) | 1994-11-30 | — | — | EP | disclosed |