Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.66 |
| ▸ | DRD2 | P14416 | 2/20 | 0.64 |
| ▸ | HTR2A | P28223 | 2/20 | 0.58 |
| ▸ | HTR2B | P41595 | 2/20 | 0.58 |
| ▸ | KDM1A | O60341 | 1/20 | 0.54 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.50 |
| ▸ | HTR1A | P08908 | 3/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30997824 | 0.91 | HTR2C (0.77) | HTR2CDRD2HTR2AHTR2BKDM1A | |
| SCHEMBL1515134 | 0.91 | HTR2C (0.77) | HTR2CDRD2HTR2AHTR2BKDM1A | |
| Methyl Alcohol SCHEMBL8097139 | 0.87 | HTR2C (0.72) | HTR2CDRD2HTR2AHTR2BKDM1A | |
| SCHEMBL7215877 | 0.86 | HTR2C (0.66) | HTR2CDRD2HTR2AHTR2BKDM1A | |
| Hydrochloric Acid SCHEMBL11831331 | 0.85 | HTR2C (0.67) | HTR2CDRD2HTR2AHTR2BKDM1A | |
| SCHEMBL28695004 | 0.84 | HTR2C (0.68) | HTR2CDRD2HTR2AHTR2BKDM1A | |
| SCHEMBL1515075 | 0.84 | HTR2C (0.72) | HTR2CDRD2HTR2AHTR2BADRA1A | |
| SCHEMBL7844832 | 0.84 | HTR2C (0.72) | HTR2CDRD2HTR2AHTR2BADRA1A | |
| SCHEMBL28695001 | 0.83 | HTR2C (0.66) | HTR2CDRD2HTR2AHTR2BADRA1A | |
| Ammonia Solution, Strong SCHEMBL19664329 | 0.82 | HTR2C (0.70) | HTR2CDRD2HTR2AHTR2BADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0747346-B1 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL MYERS SQUIBB CO (US) | 2000-02-16 | — | — | EP | disclosed |
| US-5889031-A | CONTROLLING CIRCADIAN RHYTHMS | BRISTOL-MYERS SQUIBB COMPNAY (US) | 1999-03-30 | — | — | US | disclosed |
| US-5753709-A | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-05-19 | — | — | US | disclosed |
| EP-0747346-A2 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |