Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8081420 | 0.89 | LMNA (0.41) | SMN1; SMN2ALDH1A1KDM4ELMNAPOLB | |
| SCHEMBL8089467 | 0.81 | MAPT (0.41) | SMN1; SMN2ALDH1A1KDM4ELMNATSHR | |
| SCHEMBL8081430 | 0.77 | PTK2 (0.41) | SMN1; SMN2ALDH1A1KDM4ETSHRALOX15 | |
| SCHEMBL1004434 | 0.68 | TSHR (0.40) | SMN1; SMN2ALDH1A1KDM4ETSHRMEN1 | |
| SCHEMBL1006811 | 0.64 | KDM4A (0.37) | ESR1 | |
| SCHEMBL29953023 | 0.62 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1LMNAPOLBTSHR | |
| SCHEMBL8088618 | 0.61 | MEN1 (0.45) | SMN1; SMN2ALDH1A1KDM4ELMNAPOLB | |
| SCHEMBL7052350 | 0.61 | TSHR (0.74) | SMN1; SMN2ALDH1A1LMNAPOLBTSHR | |
| SCHEMBL13844718 | 0.60 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1KDM4ELMNATSHR | |
| SCHEMBL3999663 | 0.60 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1KDM4ETSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054667-A1 | BICYCLIC PYRROLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANTIINFLAMMATORY AND IMMUNOMODULATING AGENTS | AstraZeneca UK Limited (GB) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999040913-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA UK LIMITED (GB) | 1999-08-19 | — | — | WO | disclosed |