SCHEMBL8089474

SCHEMBL8089474

BrCc1ccc(COCc2ccccc2)cc1

nearest known ligand 0.71

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.71
TRPA1 O75762 1/20 0.67
ALDH1A1 P00352 1/20 0.67
CES2 O00748 1/20 0.47
CES1 P23141 1/20 0.47
IDO1 P14902 2/20 0.46
AGXT P21549 2/20 0.44
CA1 P00915 4/20 0.42
CA2 P00918 2/20 0.42
CA7 P43166 2/20 0.42
CA9 Q16790 2/20 0.42
KDM4E B2RXH2 1/20 0.42
POLB P06746 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
TACR1 P25103 2/20 0.41
LTA4H P09960 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9795394 0.87 TSHR (0.94) TSHRIDO1AGXTCA1CA2
SCHEMBL3677409 0.86 TSHR (0.54) TSHRTRPA1ALDH1A1CES2CES1
SCHEMBL5311581 0.84 TSHR (1.00) TSHRALDH1A1IDO1AGXTCA1
SCHEMBL27380 0.84 TSHR (1.00) TSHRALDH1A1IDO1AGXTCA1
Bromoethane SCHEMBL20577437 0.83 TSHR (0.75) TSHRTRPA1ALDH1A1IDO1AGXT
SCHEMBL13570654 0.82 L3MBTL1 (0.58) TSHRTRPA1ALDH1A1IDO1TDP1
SCHEMBL9491202 0.82 TSHR (0.94) TSHRALDH1A1IDO1AGXTCA1
SCHEMBL9725547 0.82 TSHR (0.94) TSHRALDH1A1IDO1AGXTCA1
SCHEMBL1009266 0.82 TSHR (0.94) TSHRALDH1A1IDO1AGXTCA1
SCHEMBL10317949 0.82 TSHR (0.94) TSHRALDH1A1IDO1AGXTCA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6037349-A HAVING ANTAGONISTIC PROPERTIES TOWARDS ANGIOTENSIN II CAN BE USED FOR THE TREATMENT OF HYPERTENSION, ALDOSTERONISM AND CARDIAC INSUFFICIENCY MERCK PATENT GMBH (DE) 2000-03-14 US disclosed
US-5798364-A ANGIOTENSIN II ANTAGONIST, USEFUL FOR TREATMENT OF HYPERTENSION, ALDOSTERONISM AND CARDIAC INSUFFICIENCY MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1998-08-25 US disclosed
US-5332750-A Treatment of hypertension, aldosteronism, cardiac insufficienc y MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1994-07-26 US disclosed
EP-0530702-A1 1,2-dihydro-2-oxopyridines as angiotensin II antagonists MERCK PATENT GmbH (DE) 1993-03-10 EP disclosed
EP-0505893-A1 Imidazopyridines MERCK PATENT GmbH (DE) 1992-09-30 EP disclosed