SCHEMBL8089553

SCHEMBL8089553

COC(=O)Cc1ccc(Oc2cccnc2)cc1OCC(F)(F)F

nearest known ligand 0.43

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.43
LMNA P02545 2/20 0.41
TDP1 Q9NUW8 1/20 0.40
CYP19A1 P11511 1/20 0.40
METAP2 P50579 1/20 0.39
ABL1 P00519 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2C9 P11712 1/20 0.39
NPC1 O15118 1/20 0.39
TNF P01375 1/20 0.39
RAB9A P51151 1/20 0.39
NOD1 Q9Y239 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8081374 0.88 SMN1; SMN2 (0.46) SMN1; SMN2LMNATDP1CYP19A1METAP2
SCHEMBL7332593 0.82 CYP1A2 (0.40) LMNACYP1A2CYP2C9
SCHEMBL8095117 0.81 SMN1; SMN2 (0.47) SMN1; SMN2LMNATDP1CYP19A1ABL1
SCHEMBL8092950 0.78 CYP1A2 (0.44) SMN1; SMN2LMNACYP1A2CYP2C9NPC1
SCHEMBL8092952 0.78 CYP1A2 (0.48) SMN1; SMN2CYP1A2CYP2C9RAB9A
SCHEMBL8088656 0.76 MRGPRX4 (0.47) SMN1; SMN2TDP1CYP1A2CYP2C9NPC1
SCHEMBL7040523 0.75 ALDH1A1 (0.44) CYP1A2CYP2C9
SCHEMBL8088577 0.73 L3MBTL1 (0.44) SMN1; SMN2LMNACYP1A2CYP2C9L3MBTL1
Hydrochloric Acid SCHEMBL7334841 0.73 CYP1A2 (0.47) CYP1A2CYP2C9RAB9AL3MBTL1
SCHEMBL8088563 0.72 CYP1A2 (0.46) SMN1; SMN2LMNACYP1A2CYP2C9RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6090805-A Tocolytic oxytocin receptor antagonists MERCK & CO., INC. (US) 2000-07-18 US disclosed