Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13199764 | 0.69 | ADRA2A (0.41) | ADRA2ASIGMAR1TSHRATM | |
| SCHEMBL11411488 | 0.69 | CXCR5 (0.40) | ADRA2ASIGMAR1ATMHDAC9 | |
| SCHEMBL11431593 | 0.68 | NOTUM (0.40) | ADRA2AATM | |
| SCHEMBL9434726 | 0.67 | KDM1A (0.40) | SIGMAR1TSHRALDH1A1HDAC9CYP3A4 | |
| SCHEMBL10536039 | 0.67 | OPRL1 (0.43) | ADRA2ASIGMAR1TSHRALDH1A1POLB | |
| SCHEMBL30684801 | 0.67 | MMP8 (0.41) | ADRA2ASIGMAR1ATMHDAC9 | |
| SCHEMBL30818440 | 0.66 | SIGMAR1 (0.58) | ADRA2ASIGMAR1TSHR | |
| SCHEMBL3718368 | 0.65 | TSHR (0.39) | ADRA2AMEN1KMT2ASIGMAR1TSHR | |
| SCHEMBL14658768 | 0.65 | ATM (0.39) | ADRA2ASIGMAR1TSHRATMHTT | |
| SCHEMBL5586473 | 0.65 | HDAC9 (0.40) | ADRA2ASIGMAR1ATMHDAC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051394-A1 | POTASSIUM CHANNEL INHIBITORS | Icagen, Inc. (US) | 2000-11-15 | — | — | EP | disclosed |
| WO-1999037607-A1 | POTASSIUM CHANNEL INHIBITORS | ICAGEN, INC. (US) | 1999-07-29 | — | — | WO | disclosed |