SCHEMBL8089710

SCHEMBL8089710

CC(=Nc1cc(Cl)ccc1C(C)C)c1cccc(C(C)=Nc2cc(Cl)ccc2C(C)C)n1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.35
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
GAA P10253 2/20 0.35
RAB9A P51151 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
ALDH1A1 P00352 1/20 0.35
ALOX12 P18054 1/20 0.35
GFER P55789 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
PTGER1 P34995 2/20 0.34
NPC1 O15118 2/20 0.33
AGTR1 P30556 1/20 0.33
OPRK1 P41145 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
HSP90AA1 P07900 1/20 0.33
HKDC1 Q2TB90 1/20 0.33
LMNA P02545 2/20 0.33
TP53 P04637 2/20 0.33
HTT P42858 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8089708 1.00 MAPT (0.35) MAPTMEN1KMT2AGAARAB9A
SCHEMBL8094733 0.89 MAPT (0.35) MAPTMEN1KMT2AGAARAB9A
SCHEMBL8094736 0.89 MAPT (0.35) MAPTMEN1KMT2AGAARAB9A
SCHEMBL3165623 0.81 ALDH1A1 (0.49) MAPTMEN1KMT2AGAARAB9A
SCHEMBL3165619 0.81 ALDH1A1 (0.49) MAPTMEN1KMT2AGAARAB9A
SCHEMBL4618229 0.80 SIGMAR1 (0.46) MAPTMEN1KMT2AGAARAB9A
SCHEMBL4618223 0.80 SIGMAR1 (0.46) MAPTMEN1KMT2AGAARAB9A
SCHEMBL30635011 0.80 SIGMAR1 (0.46) MAPTMEN1KMT2AGAARAB9A
SCHEMBL14820625 0.79 GABRA1 (0.41) RAB9ASMN1; SMN2NPC1LMNATP53
SCHEMBL5586865 0.79 SIGMAR1 (0.45) MAPTMEN1KMT2AGAARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1059313-A1 Transition metal catalyst component for polymerization, aromatic vinyl compound-olefin copolymer and process for its production by means of the catalyst component DENKI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 2000-12-13 EP disclosed