Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 3/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.43 |
| ▸ | CCR5 | P51681 | 11/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8090771 | 0.84 | CCR5 (0.45) | CCR5OPRL1UTS2R | |
| SCHEMBL7826160 | 0.82 | CCR5 (0.65) | CCR5HRH3 | |
| SCHEMBL7838439 | 0.77 | CCR5 (0.69) | CCR5ACHE | |
| SCHEMBL7836260 | 0.76 | CCR5 (0.60) | CCR5 | |
| SCHEMBL7837491 | 0.75 | CCR5 (0.54) | CCR5OPRL1HRH3 | |
| SCHEMBL7838241 | 0.75 | CCR5 (0.50) | CCR5 | |
| SCHEMBL7872015 | 0.73 | CCR5 (0.53) | CCR5HRH3 | |
| SCHEMBL8089197 | 0.72 | CCR5 (0.56) | CCR5 | |
| SCHEMBL8082670 | 0.71 | CCR5 (0.51) | CCR5 | |
| SCHEMBL7874871 | 0.69 | CCR5 (0.60) | CCR5ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6166037-A | Pyrrolidine and piperidine modulators of chemokine receptor activity | MERCK & CO., INC. (US) | 2000-12-26 | — | — | US | disclosed |