Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 11/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 2/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | FLT1 | P17948 | 1/20 | 0.31 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | FLT4 | P35916 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8093434 | 0.97 | PIK3CD (0.35) | PIK3CDPIK3CAPOLBMAPK1JAK2 | |
| SCHEMBL8090804 | 0.88 | MTOR (0.37) | PIK3CDPIK3CAPOLBRAB9AMTOR | |
| SCHEMBL8089088 | 0.87 | PIK3CA (0.40) | PIK3CDPIK3CAMAPK1RAB9AMTOR | |
| SCHEMBL8096194 | 0.86 | KDM4E (0.39) | PIK3CDPIK3CAPOLBJAK2RAB9A | |
| SCHEMBL8098772 | 0.85 | PIK3CD (0.39) | PIK3CDPIK3CARAB9AMTORPIK3CG | |
| SCHEMBL8090187 | 0.85 | PIK3CD (0.42) | PIK3CDPIK3CAPOLBMAPK1JAK2 | |
| SCHEMBL8096233 | 0.84 | PIK3CD (0.40) | PIK3CDPIK3CAPOLB | |
| SCHEMBL8085149 | 0.84 | PIK3CA (0.39) | PIK3CDPIK3CAMAPK1RAB9AMTOR | |
| SCHEMBL8096026 | 0.84 | POLB (0.40) | PIK3CDPIK3CAPOLBMAPK1JAK2 | |
| SCHEMBL8098248 | 0.84 | PIK3CD (0.39) | PIK3CDPIK3CAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |