Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 15/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.47 |
| ▸ | MTOR | P42345 | 4/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | ATR | Q13535 | 2/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8098257 | 0.94 | PIK3CD (0.48) | PIK3CDPIK3CAMTORPIK3CBPIK3CG | |
| SCHEMBL8091084 | 0.90 | PIK3CD (0.47) | PIK3CDPIK3CAMTORPIK3CBPIK3CG | |
| SCHEMBL8091090 | 0.89 | PIK3CD (0.45) | PIK3CDPIK3CAMTORPIK3CBPIK3CG | |
| SCHEMBL8095727 | 0.88 | PIK3CD (0.43) | PIK3CDPIK3CAMTORPIK3CBPIK3CG | |
| SCHEMBL8083021 | 0.87 | PIK3CD (0.55) | PIK3CDPIK3CAMTORPIK3CBPIK3CG | |
| SCHEMBL8092629 | 0.84 | MTOR (0.48) | PIK3CDPIK3CAMTORPIK3CBPIK3CG | |
| SCHEMBL8095567 | 0.82 | PIK3CD (0.45) | PIK3CDPIK3CAMTORPIK3CBPIK3CG | |
| SCHEMBL8084603 | 0.81 | PIK3CA (0.46) | PIK3CDPIK3CAMTORPIK3CBPIK3CG | |
| SCHEMBL8083616 | 0.80 | ATR (0.42) | PIK3CDPIK3CAMTORATR | |
| SCHEMBL8083874 | 0.80 | MTOR (0.47) | PIK3CDPIK3CAMTORPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |