Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | HTR2A | P28223 | 1/20 | 0.59 |
| ▸ | HRH1 | P35367 | 1/20 | 0.59 |
| ▸ | SCN1A | P35498 | 1/20 | 0.59 |
| ▸ | SCN4A | P35499 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.59 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.59 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.59 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.59 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.59 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.59 |
| ▸ | MMP2 | P08253 | 1/20 | 0.59 |
| ▸ | MMP9 | P14780 | 1/20 | 0.59 |
| ▸ | TNKS | O95271 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4384456 | 1.00 | ALDH1A1 (0.59) | ALDH1A1CYP2C9CACNA1FMAPTHTR2A | |
| SCHEMBL542865 | 1.00 | ALDH1A1 (0.59) | ALDH1A1CYP2C9CACNA1FMAPTHTR2A | |
| SCHEMBL6282916 | 0.98 | ALDH1A1 (0.57) | ALDH1A1CYP2C9CACNA1FMAPTHTR2A | |
| SCHEMBL542225 | 0.89 | TNKS (0.62) | ALDH1A1CYP2C9CACNA1FMAPTHTR2A | |
| SCHEMBL542561 | 0.82 | LMNA (0.53) | ALDH1A1CYP2C9CACNA1FMAPTHTR2A | |
| SCHEMBL1092035 | 0.82 | MEN1 (0.49) | ALDH1A1CYP2C9CACNA1FMAPTHTR2A | |
| SCHEMBL20134878 | 0.82 | LMNA (0.53) | ALDH1A1CYP2C9CACNA1FMAPTHTR2A | |
| SCHEMBL4380000 | 0.82 | MEN1 (0.49) | ALDH1A1CYP2C9CACNA1FMAPTHTR2A | |
| SCHEMBL4380003 | 0.82 | MEN1 (0.49) | ALDH1A1CYP2C9CACNA1FMAPTHTR2A | |
| SCHEMBL10131744 | 0.80 | LMNA (0.51) | ALDH1A1CYP2C9CACNA1FMAPTHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0903353-B1 | Imidazolidine derivates, their preparation and use, and pharmaceutical compositions containing them | SANOFI AVENTIS DEUTSCHLAND (DE) | 2009-11-25 | — | — | EP | disclosed |
| EP-0816343-B1 | Process for the preparation of chiral, non-racemic (4-aryl-2,5-dioxoimidazolidin-1-yl)-acetic acids | SANOFI AVENTIS DEUTSCHLAND (DE) | 2005-12-14 | — | — | EP | disclosed |
| US-6759424-B2 | 2,5-DIOXOIMIDAZOLIDINE OR 2-THIO-5-OXOIMIDAZOLIDINE DERIVATIVES SUITABLE FOR THE THERAPY AND PROPHYLAXIS OF INFLAMMATORY DISORDERS, FOR EXAMPLE OF RHEUMATOID ARTHRITIS, OR OF ALLERGIC DISORDER | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-07-06 | — | — | US | disclosed |
| US-20030125565-A1 | Imidazolidine derivatives, their preparation, their use, and pharmaceutical preparations comprising them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2003-07-03 | — | — | US | disclosed |
| US-6423712-B1 | 2,4-Substituted imidazolidine derivatives, their preparation, their use and pharmaceutical preparations comprising them | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-07-23 | — | — | US | disclosed |
| US-6344564-B1 | FUNGICIDES | RHONE-POULENC, INC. | 2002-02-05 | — | — | US | disclosed |
| US-6018053-A | Process for the preparation of chiral, nonracemic (4-aryl-2,5-dioxoimidazolidin-1-yl) acetic acids | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-01-25 | — | — | US | disclosed |
| US-6018052-A | APPLYING TO CROPS OR THEIR SEEDS TO PREVENT OR CURE FUNGAL DISEASES; STEREOSPECIFIC COMPOUND WITH IMPROVED BIOLOGICAL ACTIVITY | RHONE-POULENC AGROCHIMIE (FR) | 2000-01-25 | — | — | US | disclosed |
| US-6008370-A | FUNGICIDAL IMIDAZOLINONE AND IMIDAZOLINETHIONE COMPOUNDS FOR USE IN PLANT PROTECTION | RHONE-POULENC AGROCHIMIE (FR) | 1999-12-28 | — | — | US | disclosed |
| US-6002016-A | Fungicidal 2-imidazolin-5-ones and 2-imidazoline-5-thiones | RHONE-POULENC AGROCHIMIE (FR) | 1999-12-14 | — | — | US | disclosed |
| EP-0903353-A1 | Imidazolidine derivates, their preparation and use, and pharmaceutical compositions containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-03-24 | — | — | EP | disclosed |
| EP-0816343-A1 | Process for the preparation of chiral, non-racemic (4-aryl-2,5-dioxoimidazolin-1-yl)-acetic acids | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-01-07 | — | — | EP | disclosed |
| US-5650519-A | Optically active 5, 5-disubstituted-3-(mono- or disubstituted amino)-2-thiohydantoin intermediates to fungicidal 2-imidazolin-5-ones | RHONE-POULENC AGROCHIMIE (FR) | 1997-07-22 | — | — | US | disclosed |
| US-5637729-A | AGRICULTURE | RHONE-POULENC AGROCHIMIE (FR) | 1997-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030125565-A1 | Imidazolidine derivatives, their preparation, their use, and pharmaceutical preparations comprising them | VCAM1, ITGA1, ITGA4 | ALDH1A1 907/4885CYP2C9 1352/4885CACNA1F 555/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.